The listings of research below represents a compilation of scientific articles found on the topic, with a very brief overview description of each article/study. This compilation of research articles does not necessarily imply that there are adequate results to demonstrate safe and/or effective human use of any herb listed.
Arzanol was identified as a major anti-inflammatory part of H. italicum. From: Bauer, J., Koeberle, A., Dehm, F., Pollastro, F., Appendino, G., Northoff, H., … & Werz, O. (2011). Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. Biochemical pharmacology, 81(2), 259-268.
It has been demonstrated that arzanol may inhibit T cells and interleukins that cause an inflammatory response. From: Tira, S., & Modica, G. D. (1967). New β-diketones from Helichrysum italicum G. Don. Tetrahedron Letters, 8(2), 143-148.
The arzanol component preserves lipoproteins from oxidative damage and reduces oxidative stress. From: Rosa, A., Deiana, M., Atzeri, A., Corona, G., Incani, A., Melis, M. P., … & Dessì, M. A. (2007). Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated α-pyrone–phloroglucinol etherodimer from Helichrysum italicum subsp microphyllum. Chemico-biological interactions, 165(2), 117-126.).
The arzanol component of H. italicum inhibits the HIV virus from replicating in T cells. From: Appendino, G., Ottino, M., Marquez, N., Bianchi, F., Giana, A., Ballero, M., … & Munoz, E. (2007). Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol α-pyrone from Helichrysum italicum ssp. microphyllum. Journal of natural products, 70(4), 608-612.