The listings of research below represents a compilation of scientific articles found on the topic, with a very brief overview description of each article/study. This compilation of research articles does not necessarily imply that there are adequate results to demonstrate safe and/or effective human use of any herb listed.
In this double blind eight week study with 69 participants, consumption of agrimony showed liver protective activities without adverse side effects. From: Cho, Y. M., Kwon, J. E., Lee, M., Lea, Y., Jeon, D. Y., Kim, H. J., & Kang, S. C. (2018). Agrimonia eupatoria L.(Agrimony) Extract Alters Liver Health in Subjects with Elevated Alanine Transaminase Levels: A Controlled, Randomized, and Double-Blind Trial. Journal of medicinal food, 21(3), 282-288.
In this randomized study with 87 obese patients, taking green cardamom three times a day for three months significantly reduced biomarkers related to fatty liver disease. From: Daneshi-Maskooni, M., Keshavarz, S. A., Qorbani, M., Mansouri, S., Alavian, S. M., Badri-Fariman, M., … & Sotoudeh, G. (2018). Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial. Nutrition & metabolism, 15(1), 63.
This study discussed carrot as hepatoprotective. From: Bishayee, A., Sarkar, A., & Chatterjee, M. (1995). Hepatoprotective activity of carrot (Daucus carota L.) against carbon tetrachloride intoxication in mouse liver. Journal of ethnopharmacology, 47(2), 69-74.
Carrot seed extract reduced oxidative stress and aided in the protection of the liver in rats. From: Singh, K., Singh, N., Chandy, A. and Maniganha, A. (2012) In Vivo Antioxidant and Hepatoprotective Activity of Methanolic Extracts of Daucus carota Seeds in Experimental Animals. Asian Pacific Journal of Tropical Biomedicine, 2, 385-388.
Clove bud oil and its constituents showed remarkable scavenging activity and hepatoprotective activity. From: Nassar, M. I., Gaara, A. H., El-Ghorab, A. H., Farrag, A., Shen, H., Huq, E., & Mabry, T. J. (2007). Chemical constituents of clove (Syzygium aromaticum, Fam. Myrtaceae) and their antioxidant activity. Revista Latinoamericana de Química, 35(3), 47.
This study assessed the antioxidant activity of coriander and caraway. From: Samojlik, I., Lakić, N., Mimica-Dukić, N., Đaković-Švajcer, K., & Božin, B. (2010). Antioxidant and hepatoprotective potential of essential oils of coriander (Coriandrum sativum L.) and caraway (Carum carvi L.)(Apiaceae). Journal of agricultural and food chemistry, 58(15), 8848-8853.
C.sempervirens and its constituents had hepatoprotective, antioxidant activity. From: Ibrahim, N. A., El-Seedi, H. R., & Mohammed, M. M. D. (2007). Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt. Natural product research, 21(10), 857-866.
F. vulgare had a potent hepatoprotective action in rats. From: Özbek, H., Uğraş, S., Dülger, H., Bayram, I., Tuncer, I., Öztürk, G., & Öztürk, A. (2003). Hepatoprotective effect of Foeniculum vulgare essential oil. Fitoterapia, 74(3), 317-319.
Foeniculum vulgare essential oil had a potent hepatoprotective action in rats. From: Hanefi, Ã., Ugras, S., Bayram, I., Uygan, I., Erdogan, E., Abdurrahman, Ã., & Huyut, Z. (2004). Hepatoprotective effect of Foeniculum vulgare essential oil: A carbon-tetrachloride induced liver fibrosis model in rats. Scandinavian Journal of Laboratory Animal Sciences, 31(1), 9-17
Thyme was liver protective in aging mice. From: Deans, S. G., Noble, R. C., Penzes, L., & Imre, S. G. (1993). Promotional effects of plant volatile oils on the polyunsaturated fatty acid status during aging. Age, 16(2), 71-74.
Carvacrol had a significant hepatoprotective and antioxidant effect in rats. From: Aristatile, B., Al‐Numair, K. S., Veeramani, C., & Pugalendi, K. V. (2009). Effect of carvacrol on hepatic marker enzymes and antioxidant status in d‐galactosamine‐induced hepatotoxicity in rats. Fundamental & clinical pharmacology, 23(6), 757-765.
Carvacrol protects the liver against defects caused by ischemia and reperfusion without being toxic in rats. From: Canbek, M., Uyanoglu, M., Bayramoglu, G., Senturk, H., Erkasap, N., Koken, T., … & Baser, K. H. C. (2008). Effects of carvacrol on defects of ischemia-reperfusion in the rat liver. Phytomedicine, 15(6), 447-452.
Extracts of Rosa damascena prevented hepatic damage from APAP−induced toxicity in rats. From: Sharma, M., Shakya, A., Sharma, N., Shrivastava, S., & Shukla, S. (2012). Therapeutic efficacy of Rosa damascena Mill. on acetaminophen-induced oxidative stress in albino rats. Journal of Environmental Pathology, Toxicology and Oncology, 31(3).
Extract of Achillea millefolium exhibited a hepatoprotective effect in mice. From: Yaeesh, S., Jamal, Q., Khan, A. U., & Gilani, A. H. (2006). Studies on hepatoprotective, antispasmodic and calcium antagonist activities of the aqueous‐methanol extract of Achillea millefolium. Phytotherapy Research, 20(7), 546-551.
Both oleanolic acid and ursolic acid were hepatoprotective in laboratory animals. They also showed anti-inflammatory, antihyperlipidemic, and antitumor effects. From: Liu, J. (1995). Pharmacology of oleanolic acid and ursolic acid. Journal of ethnopharmacology, 49(2), 57-68. Link; http://dx.doi.org/10.1016/0378-8741(95)90032-2
Hibiscus, rosemary, and sage species showed liver protective activity in rats. From: Amin, A., & Hamza, A. A. (2005). Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats. Life sciences, 77(3), 266-278.
Rosemary extract and oil demonstrated potent hepatoprotective and antimutagenic activities related to high phenolic content and antioxidant activity in rat liver. From: Fahim, F., Esmat, A., Fadel, H., & Hassan, K. (1999). Allied studies on the effect of Rosmarinus officinalis L. on experimental hepatotoxicity and mutagenesis. International Journal of Food Sciences and Nutrition, 50(6), 413-427.
Rosemary may be an effective alternative in the treatment of liver cirrhosis. From: Gutiérrez, R., Alvarado, J. L., Presno, M., Pérez‐Veyna, O., Serrano, C. J., & Yahuaca, P. (2010). Oxidative stress modulation by Rosmarinus officinalis in CCl4‐induced liver cirrhosis. Phytotherapy Research, 24(4), 595-601.
Rosemary leaf extract limited weight gain and liver steatosis in mice. From: Harach, T., Aprikian, O., Monnard, I., Moulin, J., Membrez, M., Béolor, J. C., … & Darimont, C. (2010). Rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and liver steatosis in mice fed a high-fat diet. Planta medica, 76(06), 566-571.
Root of burdock showed liver protective activity in mice. Lin, S. C., Chung, T. C., Lin, C. C., Ueng, T. H., Lin, Y. H., Lin, S. Y., & Wang, L. Y. (2000). Hepatoprotective effects of Arctium lappa on carbon tetrachloride-and acetaminophen-induced liver damage. The American journal of Chinese medicine, 28(02), 163-173.
Aucubin (an iridoid as found in plantains) showed high liver-protective activity against hepatic damage in mice and showed a potent antidotal effects on beagle dogs with mushroom poisoning. From: Chang, I. M. (1998). Liver-protective activities of aucubin derived from traditional oriental medicine. Research communications in molecular pathology and pharmacology, 102(2), 189-204.
Burdock had a hepatoprotective, antioxidant effect in mice. From: Lin, S. C., Lin, C. H., Lin, C. C., Lin, Y. H., Chen, C. F., Chen, I. C., & Wang, L. Y. (2002). Hepatoprotective effects of Arctium lappa linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. Journal of Biomedical Science, 9(5), 401-409.
Aloe phytosterols improved metabolic disorders in obese diabetic rats. From: Misawa, E., Tanaka, M., Nomaguchi, K., Nabeshima, K., Yamada, M., Toida, T., & Iwatsuki, K. (2012). Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesity-associated metabolic disorders in Zucker diabetic fatty rats. Journal of agricultural and food chemistry, 60(11), 2799-2806.
An Aloe barbadensis extraction restored integrity of hepatocytes without being toxic in mice. From: Chandan, B. K., Saxena, A. K., Shukla, S., Sharma, N., Gupta, D. K., Suri, K. A., … & Singh, B. (2007). Hepatoprotective potential of Aloe barbadensis Mill. against carbon tetrachloride induced hepatotoxicity. Journal of Ethnopharmacology, 111(3), 560-566.
Carnosol (as in rosemary) showed a liver protective effect in rats. From: Sotelo-Félix, J. I., Martinez-Fong, D., & De la Torre, P. M. (2002). Protective effect of carnosol on CCl4-induced acute liver damage in rats. European journal of gastroenterology & hepatology, 14(9), 1001-1006.
A flax and pumpkin seed mixture had a cholesterol lowering and hepatoprotective effect in rats. From: Makni, M., Fetoui, H., Gargouri, N. K., Garoui, E. M., Jaber, H., Makni, J., … & Zeghal, N. (2008). Hypolipidemic and hepatoprotective effects of flax and pumpkin seed mixture rich in ω-3 and ω-6 fatty acids in hypercholesterolemic rats. Food and Chemical Toxicology, 46(12), 3714-3720.
Compounds in yarrow had a choleretic effect in rat liver. From: Benedek, B., Geisz, N., Jäger, W., Thalhammer, T., & Kopp, B. (2006). Choleretic effects of yarrow (Achillea millefolium sl) in the isolated perfused rat liver. Phytomedicine, 13(9), 702-706.
Meadowsweet extract showed to surpass Carsil in hepatoprotective properties in vitro. From: Shilova, I. V., Zhavoronok, T. V., Souslov, N. I., Novozheeva, T. P., Mustafin, R. N., & Losseva, A. M. (2008). Hepatoprotective properties of fractions from meadowsweet extract during experimental toxic hepatitis. Bulletin of experimental biology and medicine, 146(1), 49-51
Extract from the flowers of Tilia argentea (linden) showed hepatoprotective activity in mice liver. From: Matsuda, H., Ninomiya, K., Shimoda, H., & Yoshikawa, M. (2002). Hepatoprotective principles from the flowers of Tilia argentea (linden): structure requirements of tiliroside and mechanisms of action. Bioorganic & medicinal chemistry, 10(3), 707-712.
Angelica sinensis polysaccharides-enriched fraction prevented liver toxicity induced by acetaminophen in mice. From: Ye, Y. N., Liu, E. S. L., Li, Y., So, H. L., Cho, C. C. M., Sheng, H. P., … & Cho, C. H. (2001). Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury. Life Sciences, 69(6), 637-646.
Myrrh reduced hepatic injury in vivo, similar to fom the effects of hepatitis, and warrants further research. From: Ahmad, A., Raish, M., Ganaie, M. A., Ahmad, S. R., Mohsin, K., Al-Jenoobi, F. I., … & Alkharfy, K. M. (2015). Hepatoprotective effect of Commiphora myrrha against d-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes. Pharmaceutical biology, 53(12), 1759-1767.
Noni juice was liver protective against toxic exposure in vivo. From: Wang, M. Y., Nowicki, D., Anderson, G., Jensen, J., & West, B. (2008). Liver protective effects of Morinda citrifolia (Noni). Plant foods for human nutrition, 63(2), 59-63.
Rosemary and thyme extracts were weight controlling, hepatoprotective, and hypolipidemic in vivo. From: Hegazy, A. M., Abdel-Azeem, A. S., Zeidan, H. M., Ibrahim, K. S., & Sayed, E. E. (2018). Hypolipidemic and hepatoprotective activities of rosemary and thyme in gentamicin-treated rats. Human & experimental toxicology, 37(4), 420-430.
Rosemary extracts were hepatoprotective in vivo. Mohamed, W. A., Abd-Elhakim, Y. M., & Farouk, S. M. (2016). Protective effects of ethanolic extract of rosemary against lead-induced hepato-renal damage in rabbits. Experimental and Toxicologic Pathology, 68(8), 451-461.
Constituents isolated from hops inhibited fatty liver disease in vivo. From: Mahli, A., Koch, A., Fresse, K., Schiergens, T., Thasler, W. E., Schönberger, C., … & Hellerbrand, C. (2018). Iso-alpha acids from hops (Humulus lupulus) inhibit hepatic steatosis, inflammation, and fibrosis. Laboratory Investigation, 1.