The listings of research below represents a compilation of scientific articles found on the topic, with a very brief overview description of each article/study. This compilation of research articles does not necessarily imply that there are adequate results to demonstrate safe and/or effective human use of any herb listed.
ANTINOCICEPTIVE / ANALGESIC
Marrubiin extracted from M. vulgare exhibited a potent and dose-related antinociceptive effects. From: De Jesus, R. A. P., Cechinel-Filho, V., Oliveira, A. E., & Schlemper, V. (2000). Analysis of the antinociceptive properties of marrubiin isolated from Marrubium vulgare. Phytomedicine, 7(2), 111-115.
Marrubiin extracted from horehound was analgesic in mice. From: Meyre-Silva, C., Yunes, R. A., Schlemper, V., Campos-Buzzi, F., & Cechinel-Filho, V. (2005). Analgesic potential of marrubiin derivatives, a bioactive diterpene present in Marrubium vulgare (Lamiaceae). Il Farmaco, 60(4), 321-326.
Marrubiin from horehound had an anti-inflammatory effect in induced animals. From: Stulzer, H. K., Tagliari, M. P., Zampirolo, J. A., Cechinel-Filho, V., & Schlemper, V. (2006). Antioedematogenic effect of marrubiin obtained from Marrubium vulgare. Journal of ethnopharmacology, 108(3), 379-384