Nerolidol is an sesquiterpene alcohol as found in neroli, honeysuckle, ginger, jasmine, tea tree, lemongrass, and canabis. Alcohols are the most therapeutically beneficial type of component in an essential oil, and have a low toxicity for safer use with fragile populations (like the elderly). Alcohols can be sensitizing when oxidized, so proper storage is important.
Links to Plants Containing Nerolidol
The listings of research below represent a compilation of scientific articles found on the topic, with a very brief overview description of each article/study. This compilation of research articles does not necessarily imply that there are adequate results to demonstrate safe and/or effective human use of any herb listed.
- Eugenol and nerolidol from Japanese cypress oil was topically antifungal against Microsporum gypseum on a guinea pig. From: Lee, S. J., Han, J. I., Lee, G. S., Park, M. J., Choi, I. G., Na, K. J., & Jeung, E. B. (2007). Antifungal effect of eugenol and nerolidol against Microsporum gypseum in a guinea pig model. Biological and Pharmaceutical Bulletin, 30(1), 184-188.
TRANSDERMAL DRUG DELIVERY
- The terpene nerolidol enhanced transdermal drug delivery. From: Prasanthi, D., & Lakshmi, P. K. (2012). Terpenes: Effect of lipophilicity in enhancing transdermal delivery of alfuzosin hydrochloride. Journal of advanced pharmaceutical technology & research, 3(4), 216.
- These sesquiterpenoids sensitized bacteria to antibacterial drugs and may be useful as a combination treatment: nerolidol, bisabolol, apritone, and farnesol. From: Brehm-Stecher, B. F., & Johnson, E. A. (2003). Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. Antimicrobial agents and chemotherapy, 47(10), 3357-3360.
- Essential oil constituents with an analgesic activity are reviewed. Included are p-cymene, carvacrol, linalool, eugenol, menthol, alpha-bisabolol, cinnamaldehyde, citronellal, citronellol, citronellyl acetate, alpha-phelandrene, alpha-terpeneol, vanillin, borneol, myrtenol, pulegone, citral, thymol, limonene, nerol, anethole, nerolidol, carvone, farnesol, and beta-caryphyllene. From: Lima, T., da Nóbrega, F., de Brito, A., & de Sousa, D. (2017). Analgesic-like activity of essential oil constituents: an update. International journal of molecular sciences, 18(12), 2392.
By: Kathy Sadowski