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                        Parthenolide

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                        feverfew headache relief tea

                        Parthenolide is a sesquiterpene lactone found in feverfew.  It is not water soluble.

                        Plants Containing Parthenolide

                         


                        RESEARCH

                        The listings of research below represents a compilation of scientific articles found on the topic, with a very brief overview description of each article/study.  This compilation of research articles does not necessarily imply that there are adequate results to demonstrate safe and/or effective human use of any herb listed.

                        HEADACHE RELIEF

                        • Parthenolide constituents from feverfew showed in vitro and in vivo anti-inflammatory activities.  From:  Kwok, B. H., Koh, B., Ndubuisi, M. I., Elofsson, M., & Crews, C. M. (2001). The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase. Chemistry & biology, 8(8), 759-766.

                        ANTI-INFLAMMATORY

                        • In animal studies, parthenolide was the constituent in feverfew that may reduce migraine headaches.  From:  Tassorelli, C., Greco, R., Morazzoni, P., Riva, A., Sandrini, G., & Nappi, G. (2005). Parthenolide is the component of tanacetum parthenium that inhibits nitroglycerin-induced Fos activation: studies in an animal model of migraine. Cephalalgia, 25(8), 612-621.

                        ANTI-PARASITE 

                        • Parthenolide inhibited the parasite Leishmania amazonensis in vitro. From:  Tiuman, T. S., Ueda-Nakamura, T., Cortez, D. A. G., Dias Filho, B. P., Morgado-Díaz, J. A., de Souza, W., & Nakamura, C. V. (2005). Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium. Antimicrobial agents and chemotherapy, 49(1), 176-182.

                        ANTI-CANCER 

                        • Partenolide from feverfew caused apoptosis in human colorectal cancer cells.  From:  Zhang, S., Ong, C. N., & Shen, H. M. (2004). Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. Cancer letters, 208(2), 143-153.

                        By: Kathy Sadowski

                        Updated: 1/12/19

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                        EarthtoKathy.com offers free access to lists of scientific research studies on common herbs & essential oils. Research is briefly summarized in a sentence or two, and categorized by potential therapeutic use. Plus, there are lots of easy recipes and fun blog articles to be enjoyed!

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                        Therapeutic Uses

                        • Absorption Enhancement
                        • Acne
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                        • Digestive Aid / Nausea / Constipation
                        • Female Health
                        • Green Cleaning
                        • Hair Growth / Alopecia
                        • Headache Relief
                        • Hypoglycemic / Antidiabetic
                        • Hypolipidemic / Cholesterol
                        • Immunity
                        • Insecticidal / Pesticidal
                        • Insomnia / Sleep
                        • Joint Pain / Arthritis
                        • Male Health
                        • Mouth Cold Sores
                        • Oral Health
                        • Osteoporosis
                        • Preservative
                        • Repellent
                        • Sedative / Calming
                        • Skin and Wound Health
                        • Skin Burns
                        • Stimulant / Improved Energy
                        • Sunscreen
                        • Urinary System / Diuretic / Liver
                        • Weight Loss
                        The information at www.EarthtoKathy.com is for educational purposes only and is not intended to treat, diagnose, or cure a diseases as prescribed by a physician. It does not cover all possible precautions, drug interactions, or contraindications. Seek medical care for any health issues and consult your doctor before making a change to your health regimen.

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