Piperlongumine is an alkaloid found in long pepper and other pepper species.
Links to Plants Containing Piperlongumine
RESEARCH
The listings of research below represents a compilation of scientific articles found on the topic, with a very brief overview description of each article/study. This compilation of research articles does not necessarily imply that there are adequate results to demonstrate safe and/or effective human use of any herb listed.
CARDIAC HEALTH
- Piperlongumine concentration, as found in black pepper oil, dependently inhibited platelet aggregation with antithrombosis effects in rabbits. From: Washita, M., Oka, N., Ohkubo, S., Saito, M., & Nakahata, N. (2007). Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A 2 receptor antagonist. European journal of pharmacology, 570(1), 38-42. Link; http://dx.doi.org/10.1016/j.ejphar.2007.05.073
ANTI-CANCER
- Piperlongumine reduced prostate cancer cells. From: Golovine, K. V., Makhov, P. B., Teper, E., Kutikov, A., Canter, D., Uzzo, R. G., & Kolenko, V. M. (2013). Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells. The Prostate, 73(1), 23-30.
- Piperlongumine induced colon cancer cell death. From: Randhawa, H., Kibble, K., Zeng, H., Moyer, M. P., & Reindl, K. M. (2013). Activation of ERK signaling and induction of colon cancer cell death by piperlongumine. Toxicology in vitro, 27(6), 1626-1633. Link: http://dx.doi.org/10.1016/j.tiv.2013.04.006
- Piperlongumine was effective as a therapeutic agent for the treatment of human triple negative breast cancer. From: Shrivastava, S., Kulkarni, P., Thummuri, D., Jeengar, M. K., Naidu, V. G. M., Alvala, M., … & Ramakrishna, S. (2014). Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells. Apoptosis, 19(7), 1148-1164.
By: Kathy Sadowski
Updated: 1/11/19
