Sclareol

Sclareol is a diterpene alcohol found in clary sage.

Diterpenes are not commonly found in essential oils, with a high molecular weight that is hard to steam distill.

Links to Plants Containing Sclareol

Clary Sage

RESEARCH

The listings of research below represents a compilation of scientific articles found on the topic, with a very brief overview description of each article/study.  This compilation of research articles does not necessarily imply that there are adequate results to demonstrate safe and/or effective human use of any herb listed.

ANTI-CANCER

• Sclereol killed human leukemia cells.  From:  Dimas, K., Kokkinopoulos, D., Demetzos, C., Vaos, B., Marselos, M., Malamas, M., & Tzavaras, T. (1999). The effect of sclareol on growth and cell cycle progression of human leukemic cell lines. Leukemia research, 23(3), 217-234.
• Sclareol reduced the growth rate of human colon cancer tumors in mice.  From:  Hatziantoniou, S., Dimas, K., Georgopoulos, A., Sotiriadou, N., & Demetzos, C. (2006). Cytotoxic and antitumor activity of liposome-incorporated sclareol against cancer cell lines and human colon cancer xenografts. Pharmacological research, 53(1), 80-87.
• Sclareol induced apoptosis in human breast cancer cells and also enhanced the activity of anticancer drugs.  From:  Dimas, K., Papadaki, M., Tsimplouli, C., Hatziantoniou, S., Alevizopoulos, K., Pantazis, P., & Demetzos, C. (2006). Labd-14-ene-8, 13-diol (sclareol) induces cell cycle arrest and apoptosis in human breast cancer cells and enhances the activity of anticancer drugs. Biomedicine & pharmacotherapy, 60(3), 127-133.

By: Kathy Sadowski

Updated: 1/11/19