Withaferin A is a lactone steroid as found in Acnistus arborescens and Withania sominifera (ashwagandha), both of the nightshade family of plants.
Links to Plants Containing Withaferin A
The listings of research below represents a compilation of scientific articles found on the topic, with a very brief overview description of each article/study. This compilation of research articles does not necessarily imply that there are adequate results to demonstrate safe and/or effective human use of any herb listed.
In this clinical trial of 98 chronically stressed people, an extract of ashwagandha root and leaf extract resulted in reduced cortosol levels, pulse rate, and blood pressure over 30 and 60 days. Bio-actives in the plant include withanolide glycosides and aglycodes. From: Abedon, B., & Ghosal, S. (2008). A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: a double-blind, randomized, placebo-controlled study.
Leaf extracts from ashwagandha and its withaferin constituent strongy inhibited inflammation in vitro. From: Kaileh, M., Berghe, W. V., Heyerick, A., Horion, J., Piette, J., Libert, C., … & Haegeman, G. (2007). Withaferin A strongly elicits IκB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity. Journal of Biological Chemistry, 282(7), 4253-4264.